1. Figure e-1 ? V Family A Family B Family C2 3 4 5 I II
III IV V 6 7
Figure e-1
Family A
Family B
Family C
Legend. Pedigrees of the three families with HANAC syndrome by COL4A1 mutations.
The pattern of inheritance is autosomal dominant in the three families (A, B, C). Squares denote men, circles women and slashes subjects who have died. Black symbols indicate patient with HANAC syndrome (DNA analysis was done in all affected patients but subject B.II.3 who declined it and A.I.1, A.II.2, B.I.1, C.I.1 who were deceased), white subjects unaffected and subjects with unknown status. + denote patients with direct neurological evaluation and brain MR imaging.
* Leukoencephalopathy, §Lacunar infarction, & Microbleeds, °Dilated perivascular spaces, #Intracranial aneurysm
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*& °# +