1. Genome Architecture from a Different Angle
Elizabeth H. Finn, Tom Misteli 
Developmental Cell 
Volume 41, Issue 1, Pages 3-4 (April 2017)
DOI: /j.devcel
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2. Figure 1
Schematics of Methodology of Genome Architecture Mapping and C-methods
In genome architecture mapping: physically proximal regions are selected by taking a thin section of the nuclei; individual cells are selected via microdissection; whole genomes of each nuclear section are sequenced; and interaction frequency is approximated by the number of times two loci were found in the same slice. In C-methods: physically proximal regions are selected by crosslinking, digest, and subsequent ligation; the ligation junctions are then sequenced; and interaction frequency is approximated by the number of times a given ligation junction is observed. While individual cell-level data can be generated after FACS sorting, this is not routinely done in standard C-methods.
Developmental Cell  , 3-4DOI: ( /j.devcel )
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