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Volume 19, Issue 2, Pages (April 2012)

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1 Volume 19, Issue 2, Pages 121-130 (April 2012)
Lycopene attenuates oxidative stress and heart lysosomal damage in isoproterenol induced cardiotoxicity in rats: A biochemical study  Ahmed M. Mohamadin, Ahmed A. Elberry, Amr D. Mariee, Gehan M. Morsy, Fahad A. Al-Abbasi  Pathophysiology  Volume 19, Issue 2, Pages (April 2012) DOI: /j.pathophys Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Effect of lycopene (LYC) on the activity of cardiac marker enzymes in the serum of control and isoproterenol (ISO)-induced oxidative stress and cardiotoxicity in rats. Values are the mean±SEM for 12 animals in each group. ap<0.01 compared with the control group, bp<0.01 compared with the ISO group, cp<0.01 compared with the LYC+ISO group. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Effect of lycopene (LYC) on the level of cardiac oxidative stress markers (A) GSH, (B) TBARS and (C) PCC in control and isoproterenol-(ISO) induced oxidative stress and cardiotoxicity in rats. Values are the mean±SEM for 12 animals in each group. ap<0.01 compared with the control group, bp<0.01 compared with the ISO group, cp<0.01 compared with the LYC+ISO group. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Effect of lycopene (LYC) on the level of serum antioxidants (A) GSH and (B) vitamin C in control and isoproterenol (ISO)-induced oxidative stress and cardiotoxicity in rats. Values are the mean±SEM for 12 animals in each group. ap<0.01 compared with the control group, bp<0.01 compared with the ISO group, cp<0.01 compared with the LYC+ISO group. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Effect of lycopene (LYC) on the activities of heart enzymatic antioxidants (A) SOD, (B) CAT and (C) GSH-Px in control and isoproterenol (ISO)-induced oxidative stress and cardiotoxicity in rats. Values are the mean±SEM for 12 animals in each group. ap<0.01 compared with the control group, bp<0.01 compared with the ISO group, cp<0.01 compared with the LYC+ISO group. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Effect of lycopene (LYC) on cardiac myeloperoxidase (MPO) activity in control and isoproterenol-(ISO) induced oxidative stress and cardiotoxicity in rats. Values are the mean±SEM for 12 animals in each group. ap<0.01 compared with the control group, bp<0.01 compared with the ISO group, cp<0.01 compared with the LYC+ISO group. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

7 Fig. 6 In vitro scavenging effect of lycopene on 2,2′-azinobis-(3-ethyl-benzothiazoline-6-sulfonic acid) radical (total antioxidant assay). Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions


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