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Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis:

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Presentation on theme: "Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis:"— Presentation transcript:

1 Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA)  R.F. Loeser, D.P. Beavers, A.C. Bay-Jensen, M.A. Karsdal, B.J. Nicklas, A. Guermazi, D.J. Hunter, S.P. Messier  Osteoarthritis and Cartilage  Volume 25, Issue 11, Pages (November 2017) DOI: /j.joca Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 Effects of dietary weight loss and exercise interventions on biochemical markers of type I (C1M) and type III (C3M) collagen degradation. Serum samples from baseline, 6 month and 12 month blood collections were assayed for the indicated biochemical markers. The data (expressed as ng/ml) was log transformed and adjusted for baseline values and baseline BMI and gender. Mixed models were used to assess treatment group means and pairwise differences. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Effects of dietary weight loss and exercise interventions on biochemical markers of CRP (CRPM) and type II collagen (C2M) degradation. Serum samples from baseline, 6 month and 12 month blood collections were assayed for the indicated biochemical markers. The data (expressed as ng/ml) was log transformed and adjusted for baseline values and baseline BMI and gender. Mixed models were used to assess treatment group means and pairwise differences. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions


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