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The efficacy and safety of retigabine and other adjunctive treatments for refractory partial epilepsy: A systematic review and indirect comparison  Marrissa.

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Presentation on theme: "The efficacy and safety of retigabine and other adjunctive treatments for refractory partial epilepsy: A systematic review and indirect comparison  Marrissa."— Presentation transcript:

1 The efficacy and safety of retigabine and other adjunctive treatments for refractory partial epilepsy: A systematic review and indirect comparison  Marrissa Martyn-St James, Julie Glanville, Rachael McCool, Steve Duffy, James Cooper, Pierre Hugel, Peter W. Lane  Seizure - European Journal of Epilepsy  Volume 21, Issue 9, Pages (November 2012) DOI: /j.seizure Copyright © 2012 British Epilepsy Association Terms and Conditions

2 Fig. 1 Flow diagram of the study identification process.
Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2012 British Epilepsy Association Terms and Conditions

3 Fig. 2 Conventional meta-analysis forest plots for 50% responder rate. Plots indicate the observed I2 values and associated P-value for heterogeneity from the conventional meta-analysis, along with the effect estimates and 95% CIs. Asterisks indicate an insufficient number of studies in the comparison to undertake heterogeneity testing. Diamond shape indicates overall treatment effect with 95% CIs. CI, confidence interval; OR, odds ratio; M–H, Mantel–Haenszel (fixed effects); D+L, DerSimonian and Laird (random effects). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2012 British Epilepsy Association Terms and Conditions

4 Fig. 3 Conventional meta-analysis forest plots for seizure freedom. Plots indicate the observed I2 values and associated P-value for heterogeneity from the conventional meta-analysis, along with the effect estimates and 95% CIs. Asterisks indicate an insufficient number of studies in the comparison to undertake heterogeneity testing. Diamond shape indicates overall treatment effect with 95% CIs. CI, confidence interval; OR, odds ratio; M–H, Mantel–Haenszel (fixed effects); D+L, DerSimonian and Laird (random effects). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2012 British Epilepsy Association Terms and Conditions

5 Fig. 4 Conventional meta-analysis forest plots for study withdrawals. Plots indicate the observed I2 values and associated P-value for heterogeneity from the conventional meta-analysis, along with the effect estimates and 95% CIs. Asterisks indicate an insufficient number of studies in the comparison to undertake heterogeneity testing. Diamond shape indicates overall treatment effect with 95% CIs. CI, confidence interval; OR, odds ratio; M–H, Mantel–Haenszel (fixed effects); D+L, DerSimonian and Laird (random effects). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2012 British Epilepsy Association Terms and Conditions

6 Fig. 5 Conventional meta-analysis forest plots for selected adverse events. Plots indicate the observed I2 values and associated P-value for heterogeneity from the conventional meta-analysis, along with the effect estimates and 95% CIs. Asterisks indicate an insufficient number of studies in the comparison to undertake heterogeneity testing. Diamond shape indicates overall treatment effect with 95% CIs. CI, confidence interval; OR, odds ratio; M–H, Mantel–Haenszel (fixed effects); D+L, DerSimonian and Laird (random effects). Seizure - European Journal of Epilepsy  , DOI: ( /j.seizure ) Copyright © 2012 British Epilepsy Association Terms and Conditions


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