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Simon P. Dunlop, Nicholas S. Coleman, Elaine Blackshaw, Alan C

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Presentation on theme: "Simon P. Dunlop, Nicholas S. Coleman, Elaine Blackshaw, Alan C"— Presentation transcript:

1 Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome 
Simon P. Dunlop, Nicholas S. Coleman, Elaine Blackshaw, Alan C. Perkins, Gulzar Singh, Charles A. Marsden, Robin C. Spiller  Clinical Gastroenterology and Hepatology  Volume 3, Issue 4, Pages (April 2005) DOI: /S (04) Copyright © 2005 American Gastroenterological Association Terms and Conditions

2 Figure 1 Colonic transit by radiopaque marker methods in PI-IBS and C-IBS patients vs. controls. Horizontal bar represents mean. Clinical Gastroenterology and Hepatology 2005 3, DOI: ( /S (04) ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

3 Figure 2 Postprandial release of 5-HT in PI-IBS and C-IBS patients vs. controls. Mean ± SEM error bars are shown. Clinical Gastroenterology and Hepatology 2005 3, DOI: ( /S (04) ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

4 Figure 3 AUC of 5-HT release for 3 hours after a test meal in PI-IBS and C-IBS patients vs. controls. Horizontal bar represents mean. Clinical Gastroenterology and Hepatology 2005 3, DOI: ( /S (04) ) Copyright © 2005 American Gastroenterological Association Terms and Conditions

5 Figure 4 Peak 5-HT levels in platelet-poor plasma after a 522-kcal meal in PI-IBS and C-IBS patients vs. controls. Horizontal bar shows median. Clinical Gastroenterology and Hepatology 2005 3, DOI: ( /S (04) ) Copyright © 2005 American Gastroenterological Association Terms and Conditions


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