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The Importance of Genealogy in Determining Genetic Associations with Complex Traits  Dina L. Newman, Mark Abney, Mary Sara McPeek, Carole Ober, Nancy J.

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Presentation on theme: "The Importance of Genealogy in Determining Genetic Associations with Complex Traits  Dina L. Newman, Mark Abney, Mary Sara McPeek, Carole Ober, Nancy J."— Presentation transcript:

1 The Importance of Genealogy in Determining Genetic Associations with Complex Traits 
Dina L. Newman, Mark Abney, Mary Sara McPeek, Carole Ober, Nancy J. Cox  The American Journal of Human Genetics  Volume 69, Issue 5, Pages (November 2001) DOI: /323659 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Results of two genome scans—one including pedigree structure (lighter bars) and one not including pedigree structure (darker bars)—for IgE (a), LDL (b), and BMI (c). The five most significant loci when structure is included (left sides) and when structure is not included (right sides) are shown. The American Journal of Human Genetics  , DOI: ( /323659) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Number of significantly associated (P<.01) loci when pedigree structure is included (lighter bars) and when pedigree structure is not included (darker bars). The American Journal of Human Genetics  , DOI: ( /323659) Copyright © 2001 The American Society of Human Genetics Terms and Conditions


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