1. Volume 95, Issue 1, Pages 70-77.e3 (July 2017)
Distinct Roles for the Amygdala and Orbitofrontal Cortex in Representing the Relative Amount of Expected Reward 
Rebecca A. Saez, Alexandre Saez, Joseph J. Paton, Brian Lau, C. Daniel Salzman 
Neuron 
Volume 95, Issue 1, Pages e3 (July 2017)
DOI: /j.neuron
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2. Figure 1 Contrast Revaluation Task and Behavior
(A) Sequence of events for trials (Fixation, CS appearance, trace interval, US delivery). CS2 predicts a small reward in blocks 1 and 3 and a large reward in block 2. CS1 predicts a medium reward in all blocks.
(B) Licking rate (smoothed with 5 trial sliding window) plotted versus trial number for CS1 and CS2 for one experiment. Block switches, vertical dashed lines.
(C) Mean normalized licking rate across experiments plotted versus trial number relative to the first (left) and second (right) revaluation. The sequence of trials in each panel is the longest sequence common to all experiments. Orange line, CS1; purple line, CS2. Shading, SEM.
(D) Average licking rate for each CS. Error bars: SEM. ∗∗p < 1e-06.
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3. Figure 2
Relative Reward Amounts Modulate Single-Neuron Responses in Amygdala and OFC
(A) Amygdala cell. Top: raster. Bottom: PSTHs. Vertical lines: CS onset, offset, and US onset. Orange, CS1; purple, CS2.
(B) Firing rate (smoothed with 5-trial sliding window) during CS and Trace intervals plotted versus trial number for the same cell. Block switches, vertical dashed lines.
(C and D) OFC cell, same conventions as (A) and (B). See also Figure S1.
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4. Figure 3
Relative Reward Amounts Modulate the Average Responses of Neurons Sensitive to Reward Magnitude
(A) Mean firing rate of amygdala neurons selective to amount of expected reward plotted as a function of trial number relative to the first (left) and second (right) revaluation. Each panel shows the longest sequence common to all averaged neurons. Orange, purple lines: CS1, CS2 trials. Shading, SEM.
(B) Mean firing rate of neurons in (A) for each block. Error bars: SEM. ∗∗p < 0.01 (Wilcoxon sign-rank test).
(C and D) Same as (A) and (B) except for OFC neurons.
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5. Figure 4
OFC and Amygdala Neural Activity Change at Different Rates, and Reward History Differentially Influences Activity in the Two Areas
(A and B) Mean spike density across neurons (A, OFC; B, amygdala) plotted as a function of time and trial number, aligned on the first trial where a large reward followed CS2. Horizontal solid and vertical dashed lines, block transition and CS onset. See Figure S2.
(C and D) Regression coefficients associated with reward history terms for OFC (C) and amygdala (D) (see STAR Methods). Positive coefficients: previous rewards smaller than predicted on the current trial increase neural responses. Error bars: 95% confidence intervals based on t-statistic. ∗Coefficients significantly different from 0, p < See Figure S3.
Neuron  , e3DOI: ( /j.neuron )
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