1. Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis
Shabnam Shalapour, Michael Karin 
Cell Metabolism 
Volume 23, Issue 5, Pages (May 2016)
DOI: /j.cmet
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
Fatty Acid-Induced CD4+ T Cell Depletion Promotes NAFLD-to-HCC Progression
NAFLD is associated with linoleic acid (LA) accumulation in hepatocytes. Steatotic hepatocytes secrete free LA (fLA), which is taken up by CD4+ T cell, where it undergoes β-oxidation and generates reactive oxygen species (ROS) that results in CD4+ T cell death and diminished immunosurveillance, thereby promoting liver cancer growth.
Cell Metabolism  , DOI: ( /j.cmet )
Copyright © 2016 Elsevier Inc. Terms and Conditions