1. Wavelength Tunability
Photoactivated 1,3-Dipolar Cycloaddition Reaction
Reaction Scope
Wavelength Tunability
Y. Wang, C. Vera, Q. Lin, Org. Lett. 2007, 9, 4155.
Y. Wang, et al, Q. Lin, Org. Lett. 2008, 10, 3725.
Selective Protein Labeling
302 nm, 1 min
W. Song, et al., Q. Lin, Angew. Chem. Intl. Ed. 2008, 47, 2832.
“Stapled” Peptide Therapeutics
Dr. Lin’s group is primarily interested in developing and applying new chemical tools to understand protein dynamics and function in living systems. One of the ongoing projects aims to develop a series of bioorthogonal reactions―reactions that can be carried out in aqueous media under physiological conditions―and apply them to selective protein labeling in living cells as well as synthesis of “stapled” peptide therapeutics, e.g. dual-specificity MDM2/MDMX inhibitors with potential anti-cancer activities. Another project focuses on the design of chemical probes for the ubiquitination pathway, a central biochemical pathway regulating in a wide array of biological processes such as signal transduction, cell division, and immune response. These chemical probes can not only be employed to study the mechanism of this critical biochemical pathway but also be further developed into anti-cancer drugs.
Alkene Functionalization in Living Cells
i+4 i
6.5 Å
M. Madden
W. Song, et al., Q. Lin, J. Am. Chem. Soc. 2008, 130, 9654.