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IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus  Elisha M. Singer, Daniel B. Shin,

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Presentation on theme: "IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus  Elisha M. Singer, Daniel B. Shin,"— Presentation transcript:

1 IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus  Elisha M. Singer, Daniel B. Shin, Leigh A. Nattkemper, Bernice M. Benoit, Rachel S. Klein, Chuka A. Didigu, Alison W. Loren, Tzvete Dentchev, Maria Wysocka, Gil Yosipovitch, Alain H. Rook  Journal of Investigative Dermatology  Volume 133, Issue 12, Pages (December 2013) DOI: /jid Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Peripheral blood mononuclear cell (PBMC) IL-31 mRNA and serum IL-31 correlates with marked pruritic symptoms in cutaneous T-cell lymphoma (CTCL) patients. (a) PBMCs were stimulated with phorbol 12-myristate 13-acetate (PMA)/ionomycin. IL-31 mRNA isolated from PBMCs of CTCL patients with decreasing or absent pruritus versus those with marked pruritus, P= Note that all CTCL patient mRNA values were standardized relative to the average values from a selected pool of 13 aged-matched, normal controls. Error bars: mean±SEM (n: decreasing/absent pruritus=16; marked pruritus=13). (b) Serum IL-31 levels in CTCL patients without pruritus (n=14) versus those with pruritus (n=24), P= Error bars: mean±SEM (n: no pruritus=14; pruritus=26). Note that the linear range of the assay was 7.8pgml−1 and that all samples with a value below 7.8pgml−1 or those without any detectable IL-31 were assigned a value of 7.8pgml−1 and are colored in red. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 IL-31 is produced by malignant CD4+ CD26-/CD4+ Vβ+ CTCL cells. Fifteen cutaneous T-cell lymphoma (CTCL) patients’ CD4 T cells, stimulated with phorbol 12-myristate 13-acetate (PMA)/ionomycin, were assessed for intracellular expression of IL-31 by flow cytometry. (a) Representative plots of IL-31 expression from cells without (left) and with (right) PMA/ionomycin stimulation. (b) Representative flow cytometric plot of IL-31 expression from a non-pruritic patient. (c) Representative plot of IL-31 expression from CD4+ Vβ+ CTCL cells. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

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