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HuD Stimulates Translation via eIF4A

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Presentation on theme: "HuD Stimulates Translation via eIF4A"— Presentation transcript:

1 HuD Stimulates Translation via eIF4A
Chyi-Ying A. Chen, Ann-Bin Shyu  Molecular Cell  Volume 36, Issue 6, Pages (December 2009) DOI: /j.molcel Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Models for HuD-Mediated Translation Enhancement
(A) General translation enhancement. This model proposes that HuD functions as an autonomous translation activator through its interactions with eIF4A and the poly(A) tail. (B) Transcript-specific translation enhancement. This model proposes that HuD first associates with mRNA targets through binding to adenine/uridine-rich or uridine-rich sequences (e.g., ARE) in the 3′UTRs to exert its translation-enhancing effect. AUG denotes the translation initiation codon; “stop” indicates where translation stops. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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