1. 12-CRS-0106 REVISED 8 FEB 2013 Experimental Results for a Novel Microwave Radiator Structure Targeting Non-invasive Breast Cancer Detection Arezoo Modiri, Kamran Kiasaleh University of Texas at Dallas

2. 12-CRS-0106 REVISED 8 FEB 2013 This Studys Goal Portable, Self-Examine Tool which compensates for the defects of mammography by making check ups easier and more affordable for women and sending them to X- ray or MRI monitoring only when a signature is detected. A preliminary prototype was built and tested –The design/simulation part of the project was done in Ansoft HFSS and the implementation and test parts were done through collaborations among electrical engineering, mechanical engineering and biology departments inside UTD.

3. 12-CRS-0106 REVISED 8 FEB 2013 Experimental Study Based on Simulation Analysis The following equations were calculated for a variety of tumors with different shapes placed at different locations. Adding a conductive (reflector) cover enhances the signatures in most tumor cases.

4. 12-CRS-0106 REVISED 8 FEB 2013 Radiator Fabrication 4 Dimension elite 3D printer Mechanical Eng. Department HFSS Model Solid Works Model 3D Printing

5. 12-CRS-0106 REVISED 8 FEB 2013 Creating Breast Phantom This phase of our study was done in biology lab using one of the best recipes in the literature for microwave breast phantom created by Dr. Noghanians group in the University of North Dakota. We had two trials and for each trial two breast phantoms were built, one of which had a donated breast tumor inside it. The tumor was placed inside the glandular tissue at the depth of almost 4cm. The cancer tissue was donated to us by a patient.

6. 12-CRS-0106 REVISED 8 FEB 2013 During the experiment, the phantom and the radiator were resting on a bag of ice and water. Signatures Acquired in Measurement

7. 12-CRS-0106 REVISED 8 FEB 2013 A common Network Analyzer was used for measurements & the measured data was analyzed in MATLAB to extract the cancer signatures out of phase and magnitude differences between the scattering parameters of the normal and cancerous tissues.

8. 12-CRS-0106 REVISED 8 FEB 2013 The Resonance Performance of the Antennas The resonance frequency is slightly shifted from that of simulation.

9. 12-CRS-0106 REVISED 8 FEB 2013 Adding up The Signatures Achieved Over Frequency Range of Study

10. 12-CRS-0106 REVISED 8 FEB 2013 Cumulative Signatures Over 0.4-2.6GHz As it is clear from the slope of the amplitude curves, 1-1.5GHz has the highest signature.

11. 12-CRS-0106 REVISED 8 FEB 2013 Phase signatures are more difficult to interpret and need more study.

12. 12-CRS-0106 REVISED 8 FEB 2013 Conclusion The measurements were taken over the frequency band of 0.4GHz- 2.5GHz and the signatures were studied for single-frequency and multi-frequency scenarios. The results show that the tool detects the existence of a tumor successfully in both scenarios.

13. 12-CRS-0106 REVISED 8 FEB 2013 More Needs to Be Done More accurate simulation body models –Natural changes in tissue Designing the complete measurement unit –A detection device that is easily readable not only by a physician, but also by the user herself –Miniaturization Optimization of the radiation power and exposure duration Wearable design Human Subject Tests

14. 12-CRS-0106 REVISED 8 FEB 2013 Any Questions? Arezoo.modiri@utsouthwestern.edu Thank you!