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Unlocking CNS Cell Type Heterogeneity

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Presentation on theme: "Unlocking CNS Cell Type Heterogeneity"— Presentation transcript:

1 Unlocking CNS Cell Type Heterogeneity
Ben Emery, Ben A. Barres  Cell  Volume 135, Issue 4, Pages (November 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 The TRAP Technique
BAC transgenic (bacTRAP) mice express EGFP-tagged L10a ribosomal protein (green) in targeted brain cell populations. Target tissues are dissected from the brain and lysed, and the translating ribosomes attached to mRNAs (polysomes) are stabilized with cycloheximide. Polysomes are then affinity purified with EGFP antibody-coated magnetic beads, enabling enrichment of polysomes from the cells of interest expressing the fusion protein. Affinity-purified mRNA levels are compared to the unbound mRNAs by gene profiling to assess enrichment of genes specific to the cell type of interest. Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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