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A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia–associated.

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Presentation on theme: "A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia–associated."— Presentation transcript:

1 A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia–associated antibodies in humans  Jan M.M. Heyligers, MD, PhD, Ton Lisman, PhD, Hence J.M. Verhagen, MD, PhD, Cees Weeterings, Msc, Philip G. de Groot, PhD, Frans L. Moll, MD, PhD  Journal of Vascular Surgery  Volume 47, Issue 2, Pages (February 2008) DOI: /j.jvs Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Mean levels of markers of coagulation or platelet activation in patients receiving plain expanded polytetrafluoroethylene (ePTFE) or Propaten grafts (W. L. Gore & Associates, Flagstaff, Ariz) at various times after surgery compared with preoperative levels. Error bars indicate standard error of mean. sGPV, soluble glycoprotein V; F1+2, prothrombin fragment 1+2; FPA, fibrinopeptide A; TAT, thrombin-antithrombin complexes. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Mean platelet count of patients receiving either a Propaten (W.L. Gore & Associates, Flagstaff, Ariz) or expanded polytetrafluoroethylene (ePTFE) graft at various times before and after surgery. Error bars indicate standard error of mean. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Absolute platelet count of a patient who received an expanded polytetrafluoroethylene (ePTFE) graft but was excluded from the analysis because systemic heparin was needed for 4 days postoperatively. A 45% decline in platelet count was observed at day 5, which recovered up to normal levels at week 6; moreover, no heparin/platelet factor 4 complex antibodies developed in this patient. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

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