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Jacqueline J. Russo, MD, Keira L. Barr, MD, Larissa Z

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Presentation on theme: "Jacqueline J. Russo, MD, Keira L. Barr, MD, Larissa Z"— Presentation transcript:

1 Signet ring cell melanoma, Brenner sign, and elevated vascular endothelial growth factor 
Jacqueline J. Russo, MD, Keira L. Barr, MD, Larissa Z. Scanlan, MD, Jennifer Chapman-Fredricks, MD, Loren Herrera, MD, Martin M. Dinges, MD, PhD, Vladimir Vincek, MD, PhD  Journal of the American Academy of Dermatology  Volume 65, Issue 2, Pages (August 2011) DOI: /j.jaad Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Symmetric erythematous patch referred to as Brenner sign.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Core biopsy specimen from supraclavicular mass seen in Fig 1. Note characteristic signet ring cell histomorphology. (Hematoxylin-eosin stain; original magnification: ×400.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Skin overlying Brenner sign showing mild psoriasiform dermatitis and no evidence of melanocytic abnormality. (Hematoxylin-eosin stain; original magnification: ×100.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions


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