1. Signet ring cell melanoma, Brenner sign, and elevated vascular endothelial growth factor 
Jacqueline J. Russo, MD, Keira L. Barr, MD, Larissa Z. Scanlan, MD, Jennifer Chapman-Fredricks, MD, Loren Herrera, MD, Martin M. Dinges, MD, PhD, Vladimir Vincek, MD, PhD 
Journal of the American Academy of Dermatology 
Volume 65, Issue 2, Pages (August 2011)
DOI: /j.jaad
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1 Symmetric erythematous patch referred to as Brenner sign.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

3. Fig 2
Core biopsy specimen from supraclavicular mass seen in Fig 1. Note characteristic signet ring cell histomorphology. (Hematoxylin-eosin stain; original magnification: ×400.)
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

4. Fig 3
Skin overlying Brenner sign showing mild psoriasiform dermatitis and no evidence of melanocytic abnormality. (Hematoxylin-eosin stain; original magnification: ×100.)
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions