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M. Kokki, P. Välitalo, M. Kuusisto, V. P. Ranta, K. Raatikainen, H

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Presentation on theme: "M. Kokki, P. Välitalo, M. Kuusisto, V. P. Ranta, K. Raatikainen, H"— Presentation transcript:

1 Central nervous system penetration of oxycodone after intravenous and epidural administration 
M. Kokki, P. Välitalo, M. Kuusisto, V.P. Ranta, K. Raatikainen, H. Hautajärvi, H. Kokki  British Journal of Anaesthesia  Volume 112, Issue 1, Pages (January 2014) DOI: /bja/aet337 Copyright © 2014 The Author(s) Terms and Conditions

2 Fig 1 Consort flow diagram.
British Journal of Anaesthesia  , DOI: ( /bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions

3 Fig 2 (a) Plasma and (b) CSF concentration of oxycodone after i.v. administration. The median (range) dose of oxycodone hydrochloride was (0.079–0.097) mg kg−1, administered as a 5 min infusion. British Journal of Anaesthesia  , DOI: ( /bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions

4 Fig 3 (a) Plasma and (b) CSF concentration of oxycodone after epidural administration. The median (range) dose of oxycodone hydrochloride was (0.086–0.100) mg kg−1, administered as a 5 min infusion. The CSF concentration of ng ml−1 means that the true concentration was above this upper limit of quantification. British Journal of Anaesthesia  , DOI: ( /bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions

5 Fig 4 Rescue analgesic doses of i.v. fentanyl in the two groups during the first four postoperative hours. Each hatched line corresponds to a single subject and each dot a single rescue dose of i.v. fentanyl. British Journal of Anaesthesia  , DOI: ( /bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions


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