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A Randomized, Placebo-Controlled, Multicenter, Biomarker-Selected, Phase 2 Study of Apricoxib in Combination with Erlotinib in Patients with Advanced.

Published byΘυώνη Βασιλόπουλος Modified over 5 years ago

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Presentation on theme: "A Randomized, Placebo-Controlled, Multicenter, Biomarker-Selected, Phase 2 Study of Apricoxib in Combination with Erlotinib in Patients with Advanced."— Presentation transcript:

1 A Randomized, Placebo-Controlled, Multicenter, Biomarker-Selected, Phase 2 Study of Apricoxib in Combination with Erlotinib in Patients with Advanced Non–Small-Cell Lung Cancer  Barbara J. Gitlitz, MD, Eric Bernstein, MD, Edgardo S. Santos, MD, Greg A. Otterson, MD, Ginger Milne, PhD, Mary Syto, MS, Francis Burrows, PhD, Sara Zaknoen, MD  Journal of Thoracic Oncology  Volume 9, Issue 4, Pages (April 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Consolidated Standards of Reporting Trials (CONSORT) diagram. P/E, placebo plus erlotinib; AP/E, apricoxib plus 150 mg/day erlotinib; ITT, intent-to-treat; PS, performance status. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Kaplan–Meier estimate of time to progression by treatment group in the intent-to-treat population (A) and among patients ⩽65 years of age (B). Kaplan–Meier estimate of overall survival by treatment group in the intent-to-treat population (C) and among patients ⩽65 years of age (D). P/E, placebo plus erlotinib; AP/E, apricoxib plus 150 mg/day erlotinib; HR, hazard ratio; CI, confidence interval, NA, not applicable. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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