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Volume 66, Issue 4, Pages (October 2004)

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Presentation on theme: "Volume 66, Issue 4, Pages (October 2004)"— Presentation transcript:

1 Volume 66, Issue 4, Pages 1669-1676 (October 2004)
Kinetics of urea and β2-microglobulin during and after short hemodialysis treatments  John K. Leypoldt, Alfred K. Cheung, R. Barry Deeter, Alexander Goldfarb-Rumyantzev, Tom Greene, Thomas A. Depner, John Kusek  Kidney International  Volume 66, Issue 4, Pages (October 2004) DOI: /j x Copyright © 2004 International Society of Nephrology Terms and Conditions

2 Figure 1 Time dependence of blood urea nitrogen (BUN) concentrations during and 60 minutes after short (triangles, dashed lines) and conventional (squares, solid lines) hemodialysis (HD) treatments. The final times of short and conventional HD treatments were assumed to be 120 and 240 minutes, respectively. Mean values from 21 treatment sessions for both short and conventional HD are shown. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

3 Figure 2 Postdialysis rebound of blood urea nitrogen (BUN) concentrations calculated as the increase in concentration (in absolute magnitude) from its value 10 seconds after completion of conventional (squares, solid lines) and short (triangles, dashed lines) hemodialysis (HD) treatments. BUN concentrations were not corrected for interdialytic generation of urea. Mean values from 21 treatment sessions for both conventional and short HD are shown. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

4 Figure 3 The difference between the equilibrated Kt/V (eKt/V) directly measured and that calculated by four separate rate equations plotted versus treatment time. Data from 42 treatment sessions are shown; those from patients treated with catheters are shown as open symbols. (A) Comparison with that calculated by the Daugirdas-Schneditz rate equation: the best fit linear regression equation was Y =-4.83 (±1.30) × 10-4 X (±0.025), P < (B) Comparison with that calculated by the HEMO Study rate equation: the best fit linear regression equation was Y =-3.61 (±1.40) × 10-4 X (±0.027), P = (C) Comparison with that calculated by the Tattersal et al equation: the best fit linear regression equation was Y =-2.04 (±1.33) × 10-4 X (±0.025), P = (D) Comparison with that calculated by the rate equation derived from the data in this study (equation 5,): the best fit linear regression equation was Y =-0.23 (±1.24) × 10-4 X – (±0.024), P = 0.85. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

5 Figure 4 Direct comparison of eKt/V calculated using the equation derived in this study, equation 6, with measured values of eKt/V(N = 21). Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

6 Figure 5 Time dependence of β2-microglobulin (Beta-2-M) concentrations during and 60 minutes after short (triangles, dashed lines) and conventional (squares, solid lines) hemodialysis (HD) treatments. The final times of short and conventional HD treatments were assumed as 120 and 240 minutes, respectively. Mean values from 21 treatment sessions for both short and conventional HD are shown. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions


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