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Sumana Narasimhan, MD, Ruth S. Weinstock, MD, PhD 

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1 Youth-Onset Type 2 Diabetes Mellitus: Lessons Learned From the TODAY Study 
Sumana Narasimhan, MD, Ruth S. Weinstock, MD, PhD  Mayo Clinic Proceedings  Volume 89, Issue 6, Pages (June 2014) DOI: /j.mayocp Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Figure 1 Design of the Treatment Options for Type 2 Diabetes in Adolescents and Youth study. ACE-I = angiotensin-converting enzyme inhibitor; BMI = body mass index; GAD-65 = glutamic acid decarboxylase; HbA1c = hemoglobin A1c; IA-2 = insulinoma-associated protein 2. SI conversion factors: To convert C-peptide to nmol/L, multiply by 0.331; to convert HbA1c to proportion of total hemoglobin, multiply by 0.01. Adapted from Pediatr Diabetes,19 with permission. Data also from N Engl J Med.20 Mayo Clinic Proceedings  , DOI: ( /j.mayocp ) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Figure 2 The Treatment Options for Type 2 Diabetes in Adolescents and Youth study: overall primary outcome results. Survival curves for freedom from glycemic failure are shown. Data are for up to 60 months of follow-up (accounting for 98.4% of cases of glycemic failure), although the rates and analysis are based on the complete data set. From N Engl J Med,20 with permission. Mayo Clinic Proceedings  , DOI: ( /j.mayocp ) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions


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