1. administration (single dose, 5 mg) in six healthy male volunteers.
Table 1. Plasma concentrations (µg/L) of risicodole after intravenous or peroral
administration (single dose, 5 mg) in six healthy male volunteers.
The average Clcreatinine was 100 ml/mL.
Subject 1
Subject 2
Subject 3
Subject 4
Subject 5
Subject 6
Hours IV PO
0,5
171 34
175 31 29
178 30
167
177 1
159 89
166 84
163 71
169 83
155 75
164 80
1,5
151
127
158
115
153
110
119
149
112
156
113 2
144
143
132
130
147
136
141
134
2,5
137
140
129
135
133 3
131
124
126
121
128
125 4
117
120
116 5
105
106
107
111
109
101
103 6 94 97 95 92 98 93 8 72 70 68 69 66 10 61 65 57 58 55 59 56 12 52 54 50 49 46 48 45 47 24 17 19 18 22 16 20 21