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DNA Structure & Replication

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Presentation on theme: "DNA Structure & Replication"— Presentation transcript:

1 DNA Structure & Replication
AP Biology DNA Structure & Replication

2 Nucleic Acid Structure

3 Complimentary Base Pairing

4 S Phase of Cell Cycle

5 Theta Replication in Prokaryotes
Replication fork Origin of replication Termination of replication

6 Linear Replication in Eukaryotes

7 The parent molecule has two complementary
. The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C.

8 The parent molecule has two complementary
. The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C. The first step in replication is separation of the two DNA strands.

9 Semi Conservative process of DNA Replication
The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C. The first step in replication is separation of the two DNA strands. Each parental strand now serves as a template that determines the order of nucleotides along a new, complementary strand.

10 Origins and Replication bubbles

11 DNA Replication

12 DNA Replication by adding Nucleosides on the 3’ end
New strand Template strand 5¢ end 3¢ end 5¢ end 3¢ end Sugar Base Phosphate DNA polymerase 3¢ end 3¢ end Pyrophosphate Nucleoside triphosphate 5¢ end 5¢ end

13 5 Carbon Sugar Important Parts (It could be DNA or RNA)

14 Helicase is the GREEN “blob”

15 RNA Primer (Remember, RNA is temporary)

16 DNA polymerase Pyrophosphate Nucleoside triphosphate
. New strand Template strand 5¢ end 3¢ end 5¢ end 3¢ end Sugar Base Phosphate DNA polymerase 3¢ end 3¢ end Pyrophosphate Nucleoside triphosphate 5¢ end 5¢ end

17 Nucleotide Excision Repair

18 Telomere Removal at the Chromosome Ends
End of parental DNA strands Leading strand Lagging strand Last fragment Previous fragment RNA primer Lagging strand Primer removed but cannot be replaced with DNA because no 3¢ end available for DNA polymerase Removal of primers and replacement with DNA where a 3¢ end is available Second round of replication New leading strand New leading strand Further rounds of replication Shorter and shorter daughter molecules

19 Apoptosis in the hand


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