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Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
Paul S. Knoepfler Cell Stem Cell Volume 2, Issue 1, Pages (January 2008) DOI: /j.stem Copyright © 2008 Elsevier Inc. Terms and Conditions
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Figure 1 Models of Myc Function in iPS Cell Formation
Models of three potential mechanisms by which Myc induces iPS cell formation: self-renewal through cell-cycle changes, chromatin reprogramming that possibly influences differentiation or the subsequent activity of the other three factors, and selection of a rare permissive cell. Also a combination model is presented at the bottom incorporating aspects of the individual models into a step-wise process. Cell Stem Cell 2008 2, 18-21DOI: ( /j.stem ) Copyright © 2008 Elsevier Inc. Terms and Conditions
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