1. What do your chromosomes look like?
KARYOTYPING
What do your chromosomes look like?

2. Karyotype Cell treated with chemical to stop in metaphase
Chromosomes stained
Picture taken
Enlarged
Cut out
Matched by banding patterns
Arranged by size and location of centromere

4. Click HERE to try your hand at matching up pairs of homologous chromosomes.

5. Normal Male

6. Normal Female

7. What can you tell from a Karyotype?

8. From a Karyotype You can tell Correct number of chromosomes
Correct size and shape of chromosomes
Possible sources of errors within banding patterns of the chromosomes (genes)
Gender

9. ?

10. Female with Trisomy 21 Down Syndrome

12. ??

13. Male with Trisomy 21 Down Syndrome

14. ???

15. Deletion of Long Arm Chromosome 4

16. ????

17. Extra X – Klinefelter’s Syndrome

18. ?????

19. Missing X – Turner’s Syndrome

21. SKY – Spectral Karyotypes
Uses fluorescent “tags” specific to each chromosome

23. You can also determine the type of inheritance of a disease
Dominant: at least one or both chromosomes in the pair are affected
Recessive: both chromosomes in the pair are affected.
Sex-linked: error occurs on the X chromosome
Co-dominant: the patient with only 1 of the chromosomes affected will have partial symptoms.

24. Chromosome Nomenclaturep q
11.3
11.2
11.1 12 21 22 23
11.32
11.31
11.22
11.21
11.23
12.1
12.3
12.2
21.1
21.2
21.31
21.32
21.33
22.1
22.2
22.3

25. Sources