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Covering the Cover Gastroenterology

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1 Covering the Cover Gastroenterology
Andrew T. Chan, Christopher S. Williams  Gastroenterology  Volume 152, Issue 1, Pages 1-3 (January 2017) DOI: /j.gastro Copyright © 2017 AGA Institute Terms and Conditions

2 Figure 1 Forest plot of highest vs lowest category of smoking and risk of serrated polyps. Gastroenterology  , 1-3DOI: ( /j.gastro ) Copyright © 2017 AGA Institute Terms and Conditions

3 Figure 2 Number of publications in PubMed that list the term “Crohn’s disease” OR “ulcerative colitis” OR “inflammatory bowel disease” AND the ethnic terms listed in the box (while accounting for variations of the terms, eg, “Jews” OR “Jewish” OR “Ashkenazi”). Although the results of this literature search have not been curated further (which would be necessary for more accurate estimates), the unfiltered query results reflect the representation of different ethnicities in research on inflammatory bowel disease (IBD). Although the number of new publications per year on IBD is fortunately increasing steadily (bar plot, right y-axis), reflecting a generally increasing interest in this disease (probably owing to its increasing incidence and global spreading), research in non-European ancestry cohorts has not increased throughout the years (left y-axis). An exception is studies on Asian patients; however, almost twice as many articles appear per year still on cohorts with a European ancestry. Gastroenterology  , 1-3DOI: ( /j.gastro ) Copyright © 2017 AGA Institute Terms and Conditions

4 Figure 3 Spatial and temporal diversity in human HCC revealed by multiregional deep sequencing. (A) Flowchart of study design. Multiple spatially separated tumor regions were sampled for primary culture. The enriched cancer cells were then subjected to WES and DNA copy analysis. According to the genomic profiling, biomarker-present cancer cells were treated with predicted compounds, while biomarker-absent cells underwent high-throughput screening for potential precision treatment. (B) Phylogenetic trees based on the non-silent mutations. The trunk, branch, and private branch were represented with blue, green, and red lines, respectively. The evolution distance of each tree was labeled individually, with lengths scaled to the numbers of mutations. Altered driver genes of HCC were mapped to the trunks and branches as indicated. Gene symbols in black, blue, and red denote mutations, amplifications, and deletions respectively. TERT promoter mutations were detected by Sanger sequencing and were labeled in purple. Gastroenterology  , 1-3DOI: ( /j.gastro ) Copyright © 2017 AGA Institute Terms and Conditions


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