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A Genomewide Screen of 345 Families for Autism-Susceptibility Loci

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1 A Genomewide Screen of 345 Families for Autism-Susceptibility Loci
Amanda L. Yonan, Maricela Alarcón, Rong Cheng, Patrik K.E. Magnusson, Sarah J. Spence, Abraham A. Palmer, Adina Grunn, Suh- Hang Hank Juo, Joseph D. Terwilliger, Jianjun Liu, Rita M. Cantor, Daniel H. Geschwind, T. Conrad Gilliam  The American Journal of Human Genetics  Volume 73, Issue 4, Pages (October 2003) DOI: /378778 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Multipoint MLS results from Mapmaker/Sibs ASP analysis, shown by chromosome. The X-axis depicts genetic distance in Kosambi centimorgans from pter (zero coordinate) to qter; the Y-axis represents the MLS for all autosomes and the X-MLS for the X chromosome. Thin lines represent the narrow disease classification; thick lines represent the broad disease classification (see the “Families and Methods” section). Black bars below the X-axis show regions with dense microsatellite marker coverage. The American Journal of Human Genetics  , DOI: ( /378778) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

3 Figure 1 Multipoint MLS results from Mapmaker/Sibs ASP analysis, shown by chromosome. The X-axis depicts genetic distance in Kosambi centimorgans from pter (zero coordinate) to qter; the Y-axis represents the MLS for all autosomes and the X-MLS for the X chromosome. Thin lines represent the narrow disease classification; thick lines represent the broad disease classification (see the “Families and Methods” section). Black bars below the X-axis show regions with dense microsatellite marker coverage. The American Journal of Human Genetics  , DOI: ( /378778) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

4 Figure 2 Comparison of the three stages of ASP analysis for selected chromosomes. The X-axis depicts genetic distance in Kosambi centimorgans from pter (zero coordinate) to qter; the Y-axis represents the MLS for all autosomes and the X-MLS for the X chromosome. Thick red lines represent analysis of updated stage 1 (110 families) (see the “Families and Methods” section); hatched blue lines represent analysis of stage 2 (156 families); and black lines represent analysis of stage 3 (345 families). The American Journal of Human Genetics  , DOI: ( /378778) Copyright © 2003 The American Society of Human Genetics Terms and Conditions


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