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A review of PCSK9 inhibition and its effects beyond LDL receptors

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1 A review of PCSK9 inhibition and its effects beyond LDL receptors
Dave L. Dixon, PharmD, Cory Trankle, MD, Leo Buckley, PharmD, Eric Parod, PharmD, Salvatore Carbone, MS, Benjamin W. Van Tassell, PharmD, Antonio Abbate, MD, PhD  Journal of Clinical Lipidology  Volume 10, Issue 5, Pages (September 2016) DOI: /j.jacl Copyright © 2016 National Lipid Association Terms and Conditions

2 Figure 1 Methods of PCSK9 inhibition and theorized effects of PCSK9 on various receptors. Approaches to PCSK9 inhibition include binding of circulating PCSK9 by an anti-PCSK9 antibody, or small molecule inhibitor, to prevent internalization of the LDL-R; and siRNA, and antisense oligonucleotides that inhibit expression of the PCSK9 gene, resulting in decreased extracellular and intracellular PCSK9 levels. Inhibition of PCSK9 may have additional effects beyond the LDL-R and affect cell lines from other organ systems. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 National Lipid Association Terms and Conditions

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