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The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural.

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Presentation on theme: "The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural."— Presentation transcript:

1 The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma  David Rice, MBBCh, Kari Chansky, MS, Anna Nowak, M.B.B.S., PhD, Harvey Pass, MD, Hedy Kindler, MD, Lynn Shemanski, MS, Isabelle Opitz, MD, Sergi Call, MD, Seiki Hasegawa, MD, Kemp Kernstine, MD, PhD, Cansel Atinkaya, MD, Federico Rea, MD, Philippe Nafteux, MD, Valerie W. Rusch, MD Peter Goldstraw, Ramón Rami-Porta, Hisao Asamura, David Ball, David Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, John Crowley, Frank Detterbeck, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau- Sallé, Dorothy Giroux, Fergus Gleeson, Patti Groome, James Huang, Catherine Kennedy, Jhingook Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M. Marom, Jan van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G. Nicholson, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Enrico Ruffini, Valerie Rusch, Nagahiro Saijo, Paul Van Schil, Jean-Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William Travis, Ming S. Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi-Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Eugene Blackstone, Hisao Asamura, Hasan Batirel, Andrea Bille, Ugo Pastorino, Sergi Call, Ayten K. Cangir, Susana Cedres, Joseph S. Friedberg, Francoise Galateau-Salle, Seiki Hasagawa, Kemp H. Kernstine, Hedy Kindler, Brian McCaughan, Philippe Nafteux, Kristiaan Nackaerts, Johan Vansteenkiste, Takashi Nakano, Anna Nowak, Cansel Atinkaya Ozturk, Harvey Pass, Marc de Perrot, Federico Rea, David C. Rice, Robert Rintoul, Enrico Ruffini, Valerie Rusch, Lorenzo Spaggiari, Domenico Galetta, K.N. Syrigos, Charles Thomas, Jan van Meerbeeck, Walter Weder, Isabelle Opitz, Masahiro Yoshimura David Rice, MBBCh, Kari Chansky, MS, Anna Nowak, M.B.B.S., PhD, Harvey Pass, MD, Hedy Kindler, MD, Lynn Shemanski, MS, Isabelle Opitz, MD, Sergi Call, MD, Seiki Hasegawa, MD, Kemp Kernstine, MD, PhD, Cansel Atinkaya, MD, Federico Rea, MD, Philippe Nafteux, MD, Valerie W. Rusch, MD Peter Goldstraw, Ramón Rami-Porta, Hisao Asamura, David Ball, David Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, John Crowley, Frank Detterbeck, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy Giroux, Fergus Gleeson, Patti Groome, James Huang, Catherine Kennedy, Jhingook Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M. Marom, Jan van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G. Nicholson, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Enrico Ruffini, Valerie Rusch, Nagahiro Saijo, Paul Van Schil, Jean-Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William Travis, Ming S. Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi-Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Eugene Blackstone, Hisao Asamura, Hasan Batirel, Andrea Bille, Ugo Pastorino, Sergi Call, Ayten K. Cangir, Susana Cedres, Joseph S. Friedberg, Francoise Galateau-Salle, Seiki Hasagawa, Kemp H. Kernstine, Hedy Kindler, Brian McCaughan, Philippe Nafteux, Kristiaan Nackaerts, Johan Vansteenkiste, Takashi Nakano, Anna Nowak, Cansel Atinkaya Ozturk, Harvey Pass, Marc de Perrot, Federico Rea, David C. Rice, Robert Rintoul, Enrico Ruffini, Valerie Rusch, Lorenzo Spaggiari, Domenico Galetta, K.N. Syrigos, Charles Thomas, Jan van Meerbeeck, Walter Weder, Isabelle Opitz, Masahiro Yoshimura  Journal of Thoracic Oncology  Volume 11, Issue 12, Pages (December 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Cases analyzed and reasons for exclusion.
Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Kaplan-Meier curve for survival by seventh edition American Joint Committee on Cancer clinical N category in cases with N descriptor support. MST, median survival time. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Kaplan-Meier curve for survival by seventh edition American Joint Committee on Cancer C pathologic N category in cases with N descriptor support. MST, median survival time. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Survival by seventh edition American Joint Committee on Cancer pathologic N category, single versus multiple nodal station involvement. MST, median survival time. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

6 Figure 5 Survival by seventh edition American Joint Committee on Cancer pathologic N category, N1 plus N2 involvement versus N0, pN1 and pN2 only (i.e., without N1). MST, median survival time. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

7 Figure 6 Proportion of overstaged and understaged patients according to pretreatment (clinical) N category in patients with confirmatory data on pathologic N category. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

8 Figure 7 Kaplan-Meier curve for survival by proposed eighth edition N category in cases with N descriptor support: clinical staging (A), pathologic staging (B), and “best” staging (C). MST, median survival time. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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