Presentation is loading. Please wait.

Presentation is loading. Please wait.

Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S

Published bySuzan Craig Modified over 5 years ago

Similar presentations

Presentation on theme: "Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S"— Presentation transcript:

1 Age and disease-related geometric and structural remodeling of the carotid artery 
Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S. Carson, MD, Jason N. MacTaggart, MD, B. Timothy Baxter, MD  Journal of Vascular Surgery  Volume 62, Issue 6, Pages (December 2015) DOI: /j.jvs Copyright © 2015 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Anatomy of the diseased carotid artery demonstrates the common (CCA), internal (ICA), and external (ECA) carotid arteries, the bifurcation, the bulb, and atherosclerotic plaque. The proximal bulb boundary was determined as the level at which the CCA begins to rapidly widen. The distal bulb boundary was defined as the level at which diameter of the ICA is reduced to the size of the distal ICA. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Shown is a (left) representative three-dimensional (3D) reconstruction of carotid artery geometry from two-dimensional cross-sections and (right) measurements of the geometric features in the artery. CCA, Common carotid artery; ICA, internal carotid artery. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Remodeling of the carotid geometry during normal aging demonstrates changes in the diameters, tortuosity, and bifurcation angle with age. Data are presented for the left (L) and right (R) arteries. The r values assess correlation with age. CCA, Common carotid artery; ICA, internal carotid artery. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

5 Fig 4 A representative carotid artery from a 22-year-old male demonstrates layers of elastin fibers in the (left panel) longitudinal and (right panel) transverse (circumferential) directions. C and F, Elastin in the common carotid artery (CCA) is dense and is distributed evenly through the media. B and E, In the carotid bulb, elastin becomes less dense while the artery becomes more muscular. A and D, In the internal carotid artery (ICA), elastin is concentrated mostly in the external elastic lamina, with a predominantly longitudinal orientation, whereas smooth muscle dominates in the media. Verhoeff-Van Gieson staining, with elastin stained black and collagen stained red. The scale bar = 200 μm. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Elastin density in the common carotid artery (CCA) decreases with age. Elastin density was calculated as volume fraction (%) of elastin in the medial layer. Data are presented as mean ± standard deviation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

7 Fig 6 A comparison of the longitudinal and transverse histologic sections of the proximal common carotid artery (CCA) in individuals aged (A and D) 22 years, (B and E) 43 years, and (C and F) 75 years demonstrates more fragmented and less dense elastin in the older individuals. Verhoeff-Van Gieson staining, with elastin stained black and collagen stained red. The scale bar = 200 μm. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2015 Society for Vascular Surgery Terms and Conditions

Download ppt "Alexey V. Kamenskiy, PhD, Iraklis I. Pipinos, MD, PhD, Jeffrey S"

Similar presentations

Lucy Wales, FRCS, MD, Martin Gosling, PhD, Graham W

Lucy Wales, FRCS, MD, Martin Gosling, PhD, Graham W
Aneurysm of the superior mediastinal veins

Aneurysm of the superior mediastinal veins
Karan Garg, MD, Caron B. Rockman, MD, Victoria Lee, MD, Thomas S

Karan Garg, MD, Caron B. Rockman, MD, Victoria Lee, MD, Thomas S
Bioengineered vascular access maintains structural integrity in response to arteriovenous flow and repeated needle puncture  Bryan W. Tillman, MD, PhD,

Bioengineered vascular access maintains structural integrity in response to arteriovenous flow and repeated needle puncture  Bryan W. Tillman, MD, PhD,
Xue Ma, MD, Jeffrey D. Pearce, MD, David B. Wilson, MD, William P

Xue Ma, MD, Jeffrey D. Pearce, MD, David B. Wilson, MD, William P
Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.

Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.
Coarctation-induced degenerative abdominal aortic aneurysm in a porcine model  Pao-Yen Lin, MD, Yeng-Ting Wu, MS, Guan-Cheng Lin, BS, Yao Hsiang Shih,

Coarctation-induced degenerative abdominal aortic aneurysm in a porcine model  Pao-Yen Lin, MD, Yeng-Ting Wu, MS, Guan-Cheng Lin, BS, Yao Hsiang Shih,
Chang M. He, MSc, Margot R. Roach, MD, PhD  Journal of Vascular Surgery 

Chang M. He, MSc, Margot R. Roach, MD, PhD  Journal of Vascular Surgery 
The value of 3D-CT angiographic assessment prior to carotid stenting

The value of 3D-CT angiographic assessment prior to carotid stenting
New routing alternative for proximal anterior tibial artery bypass in patients with Buerger disease  Taeseung Lee, MD, PhD, Hwan Do Ra, MD, Yang Jin Park,

New routing alternative for proximal anterior tibial artery bypass in patients with Buerger disease  Taeseung Lee, MD, PhD, Hwan Do Ra, MD, Yang Jin Park,
Histologic characterization of mobile and nonmobile carotid plaques detected with ultrasound imaging  Takeshi Funaki, MD, Koji Iihara, MD, PhD, Susumu.

Histologic characterization of mobile and nonmobile carotid plaques detected with ultrasound imaging  Takeshi Funaki, MD, Koji Iihara, MD, PhD, Susumu.
Anti–VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates  Alan B. Lumsden, MB, ChB, Changyi Chen,

Anti–VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates  Alan B. Lumsden, MB, ChB, Changyi Chen,
Neovascularization and recurrent varicose veins: more histologic and ultrasound evidence  André M van Rij, MD, FRACS, Gregory T Jones, PhD, Gerry B Hill,

Neovascularization and recurrent varicose veins: more histologic and ultrasound evidence  André M van Rij, MD, FRACS, Gregory T Jones, PhD, Gerry B Hill,
Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: An autopsy study  Søren Dalager, MD,

Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: An autopsy study  Søren Dalager, MD,
Brian G. Peterson, MD, Jon S. Matsumura, MD 

Brian G. Peterson, MD, Jon S. Matsumura, MD 
Treatment of a symptomatic intrathoracic internal carotid artery

Treatment of a symptomatic intrathoracic internal carotid artery
Jason N. MacTaggart, MD, Iraklis I. Pipinos, MD, Jason M

Jason N. MacTaggart, MD, Iraklis I. Pipinos, MD, Jason M
Treatment of a symptomatic intrathoracic internal carotid artery

Treatment of a symptomatic intrathoracic internal carotid artery
Intravascular ultrasonography allows accurate assessment of abdominal aortic aneurysm: An in vitro validation study  Jeroen A. van Essen, MD, Aad van.

Intravascular ultrasonography allows accurate assessment of abdominal aortic aneurysm: An in vitro validation study  Jeroen A. van Essen, MD, Aad van.
Histologic analysis of stent graft oversizing in the thoracic aorta

Histologic analysis of stent graft oversizing in the thoracic aorta

Similar presentations

Ads by Google