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Modeling Methuselah Cell Volume 154, Issue 1, (July 2013)

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Presentation on theme: "Modeling Methuselah Cell Volume 154, Issue 1, (July 2013)"— Presentation transcript:

1 Modeling Methuselah Cell Volume 154, Issue 1, (July 2013)
Cell  Volume 154, Issue 1, (July 2013) DOI: /j.cell Copyright © Terms and Conditions

2 NF-kB-mediated hypothalamic inflammation leads to systemic aging
NF-kB-mediated hypothalamic inflammation leads to systemic aging. Inhibiting inflammation or administration of GnRH promotes longevity. Image courtesy of D. Cai. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

3 (Left) A mouse model of progeria
(Left) A mouse model of progeria. (Right) A progeric sibling with a hypomorphic allele of ICMT. Image courtesy of M.O. Bergo. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

4 Chromosomes (blue) have short telomeres (red) in cells expressing a p53 mutant with increased activity. Image courtesy of I. Simeonova and F. Toledo. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions


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