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Uric Acid as a Target of Therapy in CKD

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Presentation on theme: "Uric Acid as a Target of Therapy in CKD"— Presentation transcript:

1 Uric Acid as a Target of Therapy in CKD
Diana I. Jalal, MD, Michel Chonchol, MD, Wei Chen, MD, PhD, Giovanni Targher, MD  American Journal of Kidney Diseases  Volume 61, Issue 1, Pages (January 2013) DOI: /j.ajkd Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Schematic representation of uric acid homeostasis. Abbreviations: CKD, chronic kidney disease; GFR, glomerular filtration rate. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Putative mechanisms by which elevated serum uric acid level may contribute to chronic kidney disease (CKD) development and progression. Abbreviations: GFR, glomerular filtration rate; MCP-1, monocyte chemotactic protein 1; NF-KB, nuclear factor-κB; NO, nitric oxide. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2012 National Kidney Foundation, Inc. Terms and Conditions


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