1. Challenges in Translational Research
TRANSLATIONAL BLOCKS
Lack of participants Career disincentives
Regulatory burden Practice limitations
Lack of infrastructure High research costs
Need for databases
Need for qualified investigators
Clinical Reseach Continuum
Sung, N. S. et al. JAMA, 2003

2. Needs of the Translational Researcher
Experienced site of practice
REMOVE THE
ROADBLOCKS
Assistance in
research oversight
Education
and training
Novel laboratory support
and product development
Assistance in protocol
development and biostatistics

3. Utilize All Resources (it takes a village to raise a translational researcher)
Cores and facilities
e.g. gene array, transgenic, pathology
Recruitment tools
Workshops
Research Centers

4. General Clinical Research Center
Funded by a grant from NIH; National Center for Research Resources
One of 78 centers around the US
UW GCRC in existence for 44 years
Provides clinical research support to investigators

5. Research Subject Advocate Program
Cell and Gene
Therapy
Core
Bionutrition
Core
Pediatric
Clinical
Care Unit
Adult
Clinical
Care Unit
Administrative Core
Education and
Biostatistical
Core
Informatics
Core
Therapeutics Development Network