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Diabetes Risk Begins In Utero

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1 Diabetes Risk Begins In Utero
Melissa Woo, Mary-Elizabeth Patti  Cell Metabolism  Volume 8, Issue 1, Pages 5-7 (July 2008) DOI: /j.cmet Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Diabetes Risk Can Begin during Prenatal Life
Intrauterine stressors, including maternal undernutrition or placental dysfunction (leading to impaired blood flow, nutrient transport, or hypoxia) can initiate abnormal patterns of development and histone modification. Additional postnatal environmental factors, including accelerated postnatal growth, obesity, inactivity, and aging can further contribute to DM risk, potentially via further histone modifications and DNA methylation in critical tissues. Cell Metabolism 2008 8, 5-7DOI: ( /j.cmet ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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