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C-C motif chemokine ligand 5 (CCL5) levels in gastric cancer patient sera predict occult peritoneal metastasis and a poorer prognosis  Tie Wang, Yuzhe.

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Presentation on theme: "C-C motif chemokine ligand 5 (CCL5) levels in gastric cancer patient sera predict occult peritoneal metastasis and a poorer prognosis  Tie Wang, Yuzhe."— Presentation transcript:

1 C-C motif chemokine ligand 5 (CCL5) levels in gastric cancer patient sera predict occult peritoneal metastasis and a poorer prognosis  Tie Wang, Yuzhe Wei, Lining Tian, Hongjiang Song, Yan Ma, Qian Yao, Meiyan Feng, Yanying Wang, Meizhuo Gao, Yingwei Xue  International Journal of Surgery  Volume 32, Pages (August 2016) DOI: /j.ijsu Copyright © 2016 IJS Publishing Group Ltd Terms and Conditions

2 Fig. 1 The serum levels of CCL5 in HC volunteers and GC patients. Gastric cancer patients had increased levels of serum CCL5, p <  GC: Gastric Cancer. International Journal of Surgery  , DOI: ( /j.ijsu ) Copyright © 2016 IJS Publishing Group Ltd Terms and Conditions

3 Fig. 2 The expression of CCL5 in surgical gastric samples. Surgical samples were fixed with 10% formalin and embedded with paraffin. Slices with thickness of 4–6 μm were cut and used for IHC staining of CCL5. Cancer-free surgical margins were used as normal mucosa. All normal mucosa samples (n = 7) had weak expression of CCL5. A. The representative pictures of IHC staining in each group. B. Patients in the CCL5 High Group expressed stronger CCL5 in primary tumor sites compared to patients in the CCL5 Low Group (p < 0.05). GC: Gastric Cancer. International Journal of Surgery  , DOI: ( /j.ijsu ) Copyright © 2016 IJS Publishing Group Ltd Terms and Conditions

4 Fig. 3 The survival of patients with gastric cancer. A. The survival curves of patients with high level of serum CCL5 (The CCL5 High Group) had poorer prognosis compared to CCL5 Low (The CCL5 Low Group), p <  B. Patients with T1-2 stage of gastric cancer were analyzed for the survival according to serum levels of CCL5 before surgery. In patients of T1-2 stages, the CCL5 Low Group had improved survivals, p <  C. The outcomes of patients with T3-4 stages were analyzed based on serum levels of CCL5. In patients of T3-4 stages, the CCL5 Low Group had a better outcome, p <  D. The survivals of gastric cancer patients with N0-1 stages were compared between the CCL5 Low Group and CCL5 High Group, p <  E. The survivals of N2-3 patients in the CCL5 Low Group and CCL5 High Group, p <  International Journal of Surgery  , DOI: ( /j.ijsu ) Copyright © 2016 IJS Publishing Group Ltd Terms and Conditions


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