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Ali N. Azadani, PhD, Sam Chitsaz, MD, Peter B

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1 Comparison of Mechanical Properties of Human Ascending Aorta and Aortic Sinuses 
Ali N. Azadani, PhD, Sam Chitsaz, MD, Peter B. Matthews, MS, Nicolas Jaussaud, MD, James Leung, MS, Tonia Tsinman, BS, Liang Ge, PhD, Elaine E. Tseng, MD  The Annals of Thoracic Surgery  Volume 93, Issue 1, Pages (January 2012) DOI: /j.athoracsur Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Custom-built biaxial stretcher used in the experiments.
The Annals of Thoracic Surgery  , 87-94DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Equibiaxial stretch data from the ascending aorta in the (A) circumferential direction and (B) longitudinal direction. Equibiaxial stretch data from the aortic sinus in the (C) circumferential direction and (D) longitudinal direction. Each geometric shape represents the experimental raw data obtained from a different human aortic root. The Annals of Thoracic Surgery  , 87-94DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Composite curves for the ascending aorta (light gray line) and aortic sinus (dark gray line) in the (A) circumferential direction and (B) longitudinal direction. Each curve is constructed using the average value of coefficients to the strain energy function. The Annals of Thoracic Surgery  , 87-94DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Comparisons of tissue stiffness for the ascending aorta and aortic sinus at (A) 72.8 kPa and (B) 120 kPa. (AA = ascending aorta; LC = left coronary; NC = noncoronary; RC = right coronary; Dark gray bars = circumferential; light gray bars = longitudinal.) The Annals of Thoracic Surgery  , 87-94DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Age dependence of ascending aorta (dark gray solid line = circumferential; light gray solid line = longitudinal) and aortic sinuses (dark gray dashed line = circumferential; light gray dashed line = longitudinal) tissue stiffness at physiologic stress level, 72 kPa and 120 kPa, respectively. Power trendlines were fitted to the experimental data. The Annals of Thoracic Surgery  , 87-94DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Histologic sections of human ascending aorta and aortic sinuses: (A) elastin-stained ascending aorta, (B) elastin-stained sinus, (C) sirius red-stained ascending aorta, and (D) sirius red-stained aortic sinus. Elastin (black), collagen fibers (red/pink), and smooth muscle (green); adventitia on top. Scale bar = 250 micrometers. The Annals of Thoracic Surgery  , 87-94DOI: ( /j.athoracsur ) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions


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