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C. Vollmer, S. Weiß, C. Beck, I. Bauer, O. Picker 

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Presentation on theme: "C. Vollmer, S. Weiß, C. Beck, I. Bauer, O. Picker "— Presentation transcript:

1 Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges 
C. Vollmer, S. Weiß, C. Beck, I. Bauer, O. Picker  British Journal of Anaesthesia  Volume 113, Issue 3, Pages (September 2014) DOI: /bja/aet462 Copyright © 2014 The Author(s) Terms and Conditions

2 Fig 1 Experimental protocol: hypoxia during normothermia (HPX), hypoxia during hypothermia (HT/HPX), hypoxia during hypothermia with glibenclamide (HT/Glib/HPX), and hypoxia during hypothermia with levosimendan (HT/Levo/HPX). British Journal of Anaesthesia  , DOI: ( /bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions

3 Fig 2 Effect of hypoxia (HPX), hypoxia during hypothermia (HT/HPX), hypoxia during hypothermia with glibenclamide (HT/Glib/HPX), and hypoxia during hypothermia with levosimendan (HT/Levo/HPX) on gastric and oral microvascular haemoglobin oxygen saturation (μHbO2). Data are presented as absolute changes zero referenced before hypoxia vs μHbO2 during hypoxia for n=5 dogs, mean (sem), *P<0.05, Fisher's PLSD. British Journal of Anaesthesia  , DOI: ( /bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions

4 Fig 3 Cardiac output in the four experimental groups over time. Data are presented as absolute values for n=5 dogs, mean (sem), *P<0.05 vs Group HT/Levo/HPX during hypoxia. British Journal of Anaesthesia  , DOI: ( /bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions

5 Fig 4 Effect of hypoxia (HPX), hypoxia during hypothermia (HT/HPX), hypoxia during hypothermia with glibenclamide (HT/Glib/HPX), and hypoxia during hypothermia with levosimendan (HT/Levo/HPX) on (a) oral mucosal perfusion (μflow), (b) oxygen delivery (μDO2), and (c) oxygen consumption (VO2). Data are presented as absolute changes zero referenced before hypoxia vs the same variable during hypoxia for n=5 dogs, mean (sem). British Journal of Anaesthesia  , DOI: ( /bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions


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