1. Metastatic Renal Cell Carcinoma: Recent Advances in the Targeted Therapy Era 
Giuseppe Di Lorenzo, Riccardo Autorino, Cora N. Sternberg 
European Urology 
Volume 56, Issue 6, Pages (December 2009)
DOI: /j.eururo
Copyright © 2009 European Association of Urology Terms and Conditions

2. Fig. 1
Biologic agents and their targets in metastatic renal cell cancer.
VHL=von Hippel-Lindau; HIF=hypoxia-inducible factor; mTOR=mammalian target of rapamycin; VEGF=vascular endothelial growth factor; PDGF=platelet-derived growth factor; TGF-α=tumour growth factor-alfa; VEGFR=vascular endothelial growth factor receptor; PDGFR=platelet-derived growth factor receptor; EGFR=epidermal growth factor; HGF=hepatocyte growth factor.
European Urology  , DOI: ( /j.eururo )
Copyright © 2009 European Association of Urology Terms and Conditions

3. Fig. 2 Management of cardiotoxicity following sunitinib treatment.
HP=hypertension; pt=patient; CHF=cardiac heart failure.
European Urology  , DOI: ( /j.eururo )
Copyright © 2009 European Association of Urology Terms and Conditions

4. Fig. 3
Memorial Sloan-Kettering Cancer Centre criteria. Absence of those criteria indicates good prognosis; presence of one or two criteria indicates intermediate prognosis; presence of three or more criteria indicates poor prognosis (presence of more than three criteria is a predictor of short survival).
LDH=lactate dehydrogenase; PS=performance status.
European Urology  , DOI: ( /j.eururo )
Copyright © 2009 European Association of Urology Terms and Conditions

5. Fig. 4 Treatment algorithm in metastatic renal cell cancer.
IFN=interferon; IL-2=interleukin-2; VEGFR=vascular endothelial growth factor receptor; TKI=tyrosine kinase inhibitor.
European Urology  , DOI: ( /j.eururo )
Copyright © 2009 European Association of Urology Terms and Conditions

6. Fig. 5 Most important ongoing phase 3 trials in renal cell cancer.
PFS=progression-free survival; OS=overall survival; QoL=quality of life; RR=response rate; DFS=disease-free survival.
European Urology  , DOI: ( /j.eururo )
Copyright © 2009 European Association of Urology Terms and Conditions