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Folic acid inhibits homocysteine-induced proliferation of human arterial smooth muscle cells  Brennan J. Carmody, MD, Subodh Arora, MD, Ricardo Avena,

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Presentation on theme: "Folic acid inhibits homocysteine-induced proliferation of human arterial smooth muscle cells  Brennan J. Carmody, MD, Subodh Arora, MD, Ricardo Avena,"— Presentation transcript:

1 Folic acid inhibits homocysteine-induced proliferation of human arterial smooth muscle cells 
Brennan J. Carmody, MD, Subodh Arora, MD, Ricardo Avena, MD, Kenyatta Cosby, BS, Anton N. Sidawy, MD  Journal of Vascular Surgery  Volume 30, Issue 6, Pages (December 1999) DOI: /S (99) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Composite photomicrograph demonstrating immunofluorescent images of secondary fluorescein isothiocyanate antibodies when primary antibodies against A, α-smooth muscle actin, B, myosin, and C, vimentin were used. Strong fluorescence of secondary antibodies is shown when primary antibodies were bound to their specific epitope. D, When no primary antibody was present, an extremely weak “random” fluorescence was observed with the addition of secondary antibodies (original magnification, 200×.) Journal of Vascular Surgery  , DOI: ( /S (99) ) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Effects of homocysteine and folic acid on cell proliferation at 6 days. *, P < .05 compared with control; +, P < .05 compared to the same concentration of homocysteine in the presence of folic acid; Hcy, homocysteine. Journal of Vascular Surgery  , DOI: ( /S (99) ) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Effects of homocysteine and folic acid on 3H-thymidine incorporation after 24 hours of incubation. *, P < .05 compared with control; +, P < .05 compared to the same concentration of homocysteine in the presence of folic acid; Hcy, homocysteine. Journal of Vascular Surgery  , DOI: ( /S (99) ) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

5 Fig. 4 Effects of folic acid/vitamins B6 and B12 combinations on homocysteine-induced cell proliferation at 6 days. Vitamins B6 and B12 did not alter cell proliferation significantly from the effect observed with folic acid alone. *, P < .05 compared to same homocysteine concentration without added folic acid or vitamins; H, homocysteine; FA, folic acid; B 6, vitamin B6; B 12, vitamin B12. Journal of Vascular Surgery  , DOI: ( /S (99) ) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

6 Fig. 5 Effects of folic acid or vitamins B6 and B12 on homocysteine-induced cell proliferation after 24 hours of incubation. *, P < .05 compared to same homocysteine concentration without added folic acid or vitamins; H, homocysteine; FA, folic acid; B 6, vitamin B6; B 12, vitamin B12. Journal of Vascular Surgery  , DOI: ( /S (99) ) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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