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UVA Research Administrators Meeting

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Presentation on theme: "UVA Research Administrators Meeting"— Presentation transcript:

1 UVA Research Administrators Meeting
Karen C. Johnston, co-Director – THRIV, iTHRIV Sandra G. Burks, Program Director – THRIV, iTHRIV September, 2018

2 Agenda Foundational THRIV iTHRIV
Overview CTSA proposal updates iTHRIV Impact on the research community iTHRIV Education / training Workforce development KL2

3 THRIV Translational Health Research Institute of Virginia
Using data to improve health Foundational program at UVA UVA Cross-Grounds initiative supported primarily by SOM Focus-integration of data science w/clinical/trans research Collaborative research infrastructure support Collaborative education/training

4 integrated THRIV Cross-state research team CTSA proposal
Leadership Council: UL1 Principal Investigators Karen C. Johnston, MD, MSc Donald E. Brown, PhD Partner Site Leadership Warren Bickel, PhD (VTC) John Niederhuber, MD (Inova) KL2 Leadership Bradford B. Worrall, MD Jason A. Papin, PhD Affiliate Leadership: COS: Brian Nosek LVG: Michael Straightiff Cross-state research team CTSA proposal

5 iTHRIV Vision Integrated research community Major challenges:
Connects across geography and discipline Establishes technical and sociological frameworks Promotes team science Major challenges: Chasm between data scientist and clinical translational researchers Chasm between patient communities and clinical scientists

6 Using Data to Improve Health
Integrated communities – using data and informatics systems Leverages and builds on existing local and cross-state infrastructures iTHRIV footprint covers ~60% population in Virginia Allow connection across geography and discipline Significant emphasis on community engagement

7 NIH Clinical & Translational Science Awards
“CTSA”-funded by NIH-NCATS since 2006 Premier clinical and translational research sites in US Innovative programs to turn scientific observations into interventions that improve the health of the public ~60 sites funded (UVA has never been funded) Traditional CTSA funds ~40% of program costs Our innovative program relates to data science/informatics

8 Required Core Components of the CTSA
[Title of the course] 27-Nov-18 Required Core Components of the CTSA Administrative Core Informatics Community and Collaboration Translational Endeavors Research Methods Hub Research Capacity Network Capacity Institutional Career Development Core (KL2) Copyright © NameOfTheOrganization. All rights reserved.

9 Review: June 2018 - Score 21(negligible weaknesses)
[Title of the course] 27-Nov-18 CTSA Timeline Submission: January 2018 Review: June Score 21(negligible weaknesses) Council: September 27, 2018 Anticipated NOA: January 2019 CTSA budget proposal (5 years): **CTSA funds expected to cover ~ 40% of total anticipated costs for program CTSA Budget (Directs) (including partner site directs) $15,564,505 UVA Total (direct + indirect) $14,583,506 CTSA Budget (Directs + Indirects) $22,964,056 Copyright © NameOfTheOrganization. All rights reserved.

10 How do THRIV and iTHRIV add value for the research community?
Combines human and technologic support Builds community engagement Fosters team science

11 Human and Technologic Support
Integrates and optimizes existing research services Includes services at partner and affiliate sites Developing shared tools and resources

12 Human and Technologic Support
Cross state shared technological/data infrastructure Personalized access to data, tools, resources Harmonized across partner sites Epic EHR I2b2/OMOP/TriNetX/SHRINE RedCap, Music, OnCore Casis (biorepository) Ivy/Rivanna Elements/VIVO Others

13 Research Concierge Portal Phase I
Implement a Virtual Map of Translational health Resources Across iTHRIV Institutions Orient investigators to research topics, tools, and resources Promote resource sharing and collaboration Demonstrate our joint identity and diverse expertise Introduce iTHRIV services (T-RECS, BERD, RKS, studios) and tools (TriNetX, VIVO, etc.) Build connection between researchers and the communities we serve (education, study recruitment, dissemination of results) Johanna Loomba – iTHRIV Research Concierge Services Manager

14 FIND RESOURCES INTERFACE

15 Community Engagement Build community relationships
Train research teams Reduce barriers to research participation Increase special populations in trials Expand community based participatory research iTHRIV Community Engagement Advisory Boards Dedicated iTHRIV Partnership Manager (Kristin Miller)

16 Team Science: Seed Grants
First round – UVA/Inova Collaboration Awards ( ) 8 funded projects Co-PIs UVA and Inova faculty Several abstracts presented 1 grant submitted Manuscripts in preparation Future seed grants both internal and via CTSA

17 Team Science: THRIV/iTHRIV Studios
Moderated forum to share expertise, foster team science, promote excellence CTSA/Vanderbilt University model iTHRIV Studio Lead: Jaideep Kapur Studio Manager: Johanna Loomba Initial Programs at UVA Brain Institute THRIV scholars K to R transition Opportunities: All iTHRIV sponsored seed grants Other….

18 iTHRIV Education and Training:
iTHRIV mission includes commitment to growing the next generation of clinical translational researchers. Workforce development KL2/THRIV Scholars

19 Education and Training: Workforce Development
Developing efficiencies for training and supporting research teams Core competencies for clinical translational research CRC education Best practices for research process

20 Education and Training: THRIV / iTHRIV KL2 Scholars
Junior faculty mentored career development program THRIV Scholars – internally funded UVA program THRIV Scholars: Foundational for proposed iTHRIV KL2 program VT Scholars: developing program iTHRIV KL2 to integrate VTC & Inova faculty

21 Bradford Worrall, MD, MSc
THRIV / iTHRIV KL2 Scholars Jason Papin, PhD Bradford Worrall, MD, MSc Jason Papin, PhD Bradford Worrall, MD, MSc

22 2017-2019 UVA THRIV Scholars Scholar Research Proposal Primary Mentor
Jessica Keim-Malpass, PhD, RN, Acute & Specialty Care, SON A pragmatic clinical trial evaluating impact of continuous predictive monitoring on nurse-driven outcomes in a dynamic intensive care setting. J. Randall Moorman, MD Kyle J. Lampe, PhD, Chemical Engineering, SEAS Bioengineered hydrogels to facilitate 3D neural stem cell survival and growth in a stroke environment. Brad Worrall, MD Kathleen McManus, MD, MS, Infectious Disease, SOM Affordable care act's effects on persons living with HIV (PLWH) in Virginia. Rebecca Dillingham, MD, MPH Brynne Sullivan, MD, Pediatrics, Pulse oximetry cardiorespiratory scores to predict adverse events and outcomes in premature infants. Dustin Walters, MD, Surgery, The role of CD8+ TCell mediated tolerance in non-small cell lung cancer. Sasha Krupnick MD Nicole

23 2018-2020 UVA THRIV Scholars THRIV Scholar Research Proposal
Primary Mentor J. Nicholas Brenton, MD, Neurology and Pediatrics, SOM Application of a ketogenic diet in relapsing-remitting multiple sclerosis Karen Johnston, MD, MSc Myla Goldman, MD, MSc Meghan Mattos, PhD, RN, CNL, Acute-Specialty Care, SON Use of an internet-based intervention to prevent cognitive decline in older adults with mild cognitive impairment Lee Ritterband, PhD, Carol Manning, PhD Thomas Hartka, MD, MS, Emergency Medicine, Predicting injury risk after motor vehicle collision using occupant / vehicle telemetry data Mark Sochor, MD Sana Syed, MBBS, MS, Pediatrics, Computational modeling of intestinal mucosa: image analysis and multiomics Sean Moore, MD Nicole NeuroNext Scholar (1 year) Primary Mentor Andrew Schomer, MD, Neurology, SOM Jaideep Kapur, MBBS, PhD

24 iTHRIV cross state team

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