1. Targeting Epigenetics to Speed Up Repair
Eric Soler, Frank Grosveld 
Cell Stem Cell 
Volume 14, Issue 5, Pages (May 2014)
DOI: /j.stem
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure 1
Enhanced Recovery from Ischemic Injury by ECFCs Pretreated with TSA
Ischemic injury results in interrupted or lower blood supply to affected tissue. Injection of ECFCs helps rescue the blood flow by generating new vasculature at the site of injury. The transcription factor TAL1 is a key factor controlling this process in ECFCs. TAL1 positively regulates target genes by cooperating with the histone acetyl transferase p300. This action is turned down by histone deacetylases (HDACs). Treatment with TSA, an HDAC inhibitor, modifies the balance between TAL1/p300 and HDACs and enhances TAL1 target gene expression in ECFCs, resulting in faster recovery after ischemic injury.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2014 Elsevier Inc. Terms and Conditions