1. Pharmacovigilance
What? (2.6) Ensure ADR monitoring (Spontaneous reporting/Cohort studies)
Who? Healthcare workers
How? WHO International Drug Monitoring Programme
Partners: WHO, WHO CC, Countries NPC (79)
Here: Ghana, South Africa, Tanzania, Zambia
Others: HQ and Country offices
Beyond PSM: An entry point for pharmacovigilance
(Access to Global ADR Data of 3.5 million reports, causality experts, forecasting resistance, treatment guidelines)

2. Pharmacovigilance Dr Shanthi Pal, Quality Assurance and Safety of Medicines, WHO
To undergo treatment you have to be very healthy, because apart from your sickness you have to withstand the medicine.
Molière

3. Public Health Programmes
What?
How?
Benefit risk assessment?
ADR reporting, PV?

4. PV in PHP: Why? 5 Ds (Diagnosis, diseases, drug, diet, DRA)
It is not always the product that determines drug safety but how it is used

5. Eroding confidence in the malaria programme

6. Italian
Cohort
Main reasons of discontinuation of first HAART regimen within st year: ICONA I C O N A
Naive
Antiretroviral
Monforte et al. AIDS 1999

7. WHO-PV (UMC) PATIENTS PATIENTS Health workers INTEGRATING P.H.P AND PV
FUNCTIONAL AND STRUCTURAL RELATIONSHIP
T r a c h o m a t i s
F i l a r i a s i s
T u b e r c u l o s i s
M a l a r i a
V a c c i n e s
WHO-PV
(UMC)
WHO ADVISORY
COMMITTEE
W.H.O
PROGRAMMES
DRUG REGULATORY AUTHORITY
Expert Safety Review
Panel
T r a c h o m a t i s
F i l a r i a s i s
T u b e r c u l o s i s
M a l a r i a
PV Coordinator
National PV centre
V a c c i n e s
NATIONAL PUBLIC HEALTH PROGRAMMES
DISTRICT INVESTIGATION TEAM
PATIENTS
PATIENTS
Health workers

8. Procurement and Supply Management Plan
2.6 Ensuring rational use of medicines
Is there a system for monitoring adverse drug reactions and drug resistance? If yes, describe briefly how the system works. If no, describe plans to establish a system.

9. "Dying from a disease is sometimes unavoidable
"Dying from a disease is sometimes unavoidable. But, dying from an adverse drug reaction is unacceptable".
Dr Vladimir Lepakhin
Geneva 2005