1. Canadian Cardiovascular Society Guidelines on the Use of Cardiac Resynchronization Therapy: Evidence and Patient Selection 
Derek V. Exner, MD, MPH, David H. Birnie, MBChB, MD, Gordon Moe, MD, Bernard Thibault, MD, François Philippon, MD, Jeffrey S. Healey, MSc, MD, Anthony S.L. Tang, MD, Éric Larose, DVM, MD, Ratika Parkash, MD, MSc 
Canadian Journal of Cardiology 
Volume 29, Issue 2, Pages (February 2013)
DOI: /j.cjca
Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions

2. Figure 1
Random effects model for overall mortality in patients treated with cardiac resynchronization therapy (CRT) plus medical therapy or CRT plus an implantable cardioverter-defibrillator (ICD) vs their comparators. Random effects meta-analysis of overall mortality among patients with mildly symptomatic (New York Heart Association I-II) and advanced (III-IV) heart failure treated with CRT added to medical therapy or with CRT added to ICD. Values less than 1.0 indicate decreased risk of mortality with CRT. CARE-HF, Cardiac Resynchronization in Heart Failure; COMPANION, Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure; MADIT-CRT, Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy; MIRACLE, Multicenter InSync ICD Randomized Clinical Evaluation; MUSTIC-SR, Multisite Stimulation in Cardiomyopathies Sinus Rhythm; RAFT, Resynchronization/Defibrillation for Ambulatory Heart Failure Trial; REVERSE, Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction; RHYTHM, Resynchronization for Hemodynamic Treatment for Heart Failure Management; VECTOR, Ventricular Resynchronization Therapy Randomized Trial.
Adapted from Wells et al.7
Canadian Journal of Cardiology  , DOI: ( /j.cjca )
Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions

3. Figure 2
Random-effects model for overall mortality in those treated with CRT-D vs an ICD alone, stratified by NYHA class. Random-effects meta-analysis of overall mortality with mildly symptomatic (NYHA I-II) and advanced (III-IV) heart failure treated with CRT-D vs an ICD. Values less than 1.0 indicate decreased risk of mortality with CRT. CRT, cardiac resynchronization therapy; CRT-D, CRT plus implantable cardioverter-defibrillator; ICD, implantable cardioverter-defibrillator; MADIT-CRT, Multicenter Automatic Defibrillator Implantation Trial - Cardiac Resynchronization Therapy; MIRACLE, Multicenter InSync ICD Randomized Clinical Evaluation; NYHA, New York Heart Association; RAFT, Resynchronization/Defibrillation for Ambulatory Heart Failure Trial; REVERSE, Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction; RHYTHM, Resynchronization for Hemodynamic Treatment for Heart Failure Management.
Adapted from Wells et al.7
Canadian Journal of Cardiology  , DOI: ( /j.cjca )
Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions