Presentation is loading. Please wait.

Presentation is loading. Please wait.

Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma  Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran,

Published byJoseph Dupont Modified over 6 years ago

Similar presentations

Presentation on theme: "Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma  Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran,"— Presentation transcript:

1 Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma  Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran, BSc, Zoe Corden, BSc, Malcolm Boyce, FRCP, Hasan Arshad, MD, Stephen Holgate, MD, Brian O'Connor, MD, Sylvaine Millet, BSc, Barry Miller, MS, Shashank Rohatagi, PhD, Stephane Kirkesseli, MD  Journal of Allergy and Clinical Immunology  Volume 116, Issue 4, Pages (October 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Pharmacokinetics of IVL745 (mean [SD]) on day 8, with IC50 VLA-fibronectin and IC50 VLA–VCAM-1 values shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Mean change (percentage) in FEV1 from prechallenge value in the 9 hours after allergen inhalation on day 8 for placebo and IVL745. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Percentage of eosinophils and neutrophils in sputum on day 7 (error bars indicate SEM). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Download ppt "Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma  Virginia Norris, MRCP, Lee Choong, BSc, Duyen Tran,"

Similar presentations

Bronchial challenges in athletes applying to inhale a β2-agonist at the 2004 Summer Olympics Sandra D. Anderson, PhD, DSc, Malcolm Sue-Chu, MB ChB, PhD,

Bronchial challenges in athletes applying to inhale a β2-agonist at the 2004 Summer Olympics Sandra D. Anderson, PhD, DSc, Malcolm Sue-Chu, MB ChB, PhD,
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.
Severe adult-onset asthma: A distinct phenotype

Severe adult-onset asthma: A distinct phenotype
Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life  Carina Venter, BSc, Brett Pereira, MRCP, Jane.

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life  Carina Venter, BSc, Brett Pereira, MRCP, Jane.
D-dimer: A biomarker for antihistamine-resistant chronic urticaria

D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
What drives prescription patterns in pediatric asthma management?

What drives prescription patterns in pediatric asthma management?
Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.
Allergen immunotherapy: A practice parameter third update

Allergen immunotherapy: A practice parameter third update
Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 
Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life  Carina Venter, BSc, Brett Pereira, MRCP, Jane.

Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life  Carina Venter, BSc, Brett Pereira, MRCP, Jane.
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids  Kittipong Maneechotesuwan, MD, PhD, Sirinya.
Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD 

Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD 
Epidemic asthma and the role of the fungal mold Alternaria alternata

Epidemic asthma and the role of the fungal mold Alternaria alternata
David A. Khan, MD  Journal of Allergy and Clinical Immunology 

David A. Khan, MD  Journal of Allergy and Clinical Immunology 
Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD 
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Desensitization to Chemotherapeutic Agents

Desensitization to Chemotherapeutic Agents

Similar presentations

Ads by Google