1. Concentration-dependent suppression of F-waves by sevoflurane does not predict immobility to painful stimuli in humans† 
J.H. Baars, D. Kalisch, K.F. Herold, D.A. Hadzidiakos, B. Rehberg 
British Journal of Anaesthesia 
Volume 95, Issue 6, Pages (December 2005)
DOI: /bja/aei252
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Original tracings of M-wave and F-wave (a) before anaesthesia and (b) under 1.0% end-tidal sevoflurane concentration (stimulus intensity 24 mA).
British Journal of Anaesthesia  , DOI: ( /bja/aei252)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Individual hysteresis loops (effect vs end-tidal sevoflurane concentration) and collapsed loops (effect vs effect compartment concentrations) of the different drug effect measures. Original data from all patients. The collapsed curves were generated from the individual equilibration time constants. To estimate the goodness of the fit the grey line shows the mean concentration–response curve of all patients (see Fig. 4). Loops for F-wave amplitude are shown in (a) and (b), for F-wave persistence in (c) and (d) and for the BIS in (e) and (f). BIS values were recorded only every 20 s; therefore the BIS loops have fewer data points. Because of the high interindividual variability the F-wave amplitude was normalized to individual control values.
British Journal of Anaesthesia  , DOI: ( /bja/aei252)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
(a) EC50, (b) equilibration half-time and (c) Hill coefficient (λ) time derived from the individual sigmoidal PK–PD modelling of the drug effects examined. Horizontal bar, mean value for EC50 and equilibration half-time; median for Hill coefficient. (F-wave amplitude and persistence, n=27; BIS, n=23.)
British Journal of Anaesthesia  , DOI: ( /bja/aei252)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Comparison of the sigmoidal concentration–response curves for suppression of F-wave amplitude, F-wave persistence, and bispectral index. These curves were generated from the mean values of the computer fits of all individual concentration–response curves at each concentration. The broken line shows the logistic regression curves for the suppression of the motor response to noxious electrical stimulation. Horizontal error bars, standard errors of the EC50 values; circles, individual movement response (filled circles, response; open circles, no response). For the BIS, F-wave amplitude and persistence the x-axis displays the effect site concentrations, whereas the logistic regression curve is based on end-tidal concentrations.
British Journal of Anaesthesia  , DOI: ( /bja/aei252)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
Response of F-wave amplitude to noxious electrical stimulation (t=0 s; stimulus intensity: 50 Hz, 60 mA, 5 s, 0.2 ms square wave) for (a) patients who did not move after stimulation (non-movers) and (b) patients who did move (movers). Data are expressed as mean (sd).
British Journal of Anaesthesia  , DOI: ( /bja/aei252)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

7. Fig 6
Consecutive EMG tracings around noxious stimulation in one patient. The noxious stimulation was performed during end-tidal sevoflurane concentrations of 2%. The patient did not move after stimulation. Background noise remained stable during the tetanic stimulation at the wrist which did not cause any recordable artifacts.
British Journal of Anaesthesia  , DOI: ( /bja/aei252)
Copyright © 2005 British Journal of Anaesthesia Terms and Conditions