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A Circuit Mechanism for Neurodegeneration

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Presentation on theme: "A Circuit Mechanism for Neurodegeneration"— Presentation transcript:

1 A Circuit Mechanism for Neurodegeneration
Francesco Roselli, Pico Caroni  Cell  Volume 151, Issue 2, Pages (October 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Circuit Basis for Selective Degeneration of Motoneurons in a Drosophila Model of SMA Motoneurons receive indirect excitatory inputs from cholinergic sensory and cholinergic spinal interneurons. Under wild-type conditions, normal levels of SMN protein ensure correct splicing and proper levels of Stasimon mRNA and proper excitation of the cholinergic neurons and functional motoneurons (left). Upon loss of SMN, residual SMN protein from a maternal mRNA pool is insufficient to properly splice Stasimon transcript, leading to reduced accumulation of its mRNA (right). This leads to reduced excitation of the cholinergic neurons and to motoneuron degeneration. Cell  , DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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