1. Bone Biology and Osteoporosis: Back to the Basics

2. Learning Objectives

4. Who Is at Risk for Osteoporosis?

7. Most Women With Hip Fractures Do Not Have a T score ≤ -2.5

8. FRAX

9. FRAX Clinical Risk Factors

13. Who Should Be Treated?

16. RANKL Is Implicated in Bone Loss Across a Broad Range of Conditions

17. Potential Strategies for Downregulating RANKL

18. Wnt Signaling Pathway

19. Inhibition of Sclerostin Stimulates Bone Formation

20. PTH Inhibits Sclerostin and Stimulates Bone Formation

22. Inhibition of Cathepsin K Inhibits Bone Resorption

23. Individualizing Treatment Decisions

24. Individual Patient Factors

25. Clinical Challenges After Starting Treatment

26. Summary

27. Abbreviations

28. Abbreviations (cont)

29. References

30. References (cont)