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Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data  Denise S.K. Brookes, Julie N.

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Presentation on theme: "Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data  Denise S.K. Brookes, Julie N."— Presentation transcript:

1 Cystic fibrosis-related bone disease in children: Examination of peripheral quantitative computed tomography (pQCT) data  Denise S.K. Brookes, Julie N. Briody, Craig F. Munns, Peter S.W. Davies, Rebecca J. Hill  Journal of Cystic Fibrosis  Volume 14, Issue 5, Pages (September 2015) DOI: /j.jcf Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

2 Fig. 1 vBMD, bone CSA and BSIc at the 4% tibia site: (A) pre-pubertal males and females, CF (blue or pink) vs Controls; (B) pubertal males and females, CF (blue or pink) vs Controls, mean (SD). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

3 Fig. 2 vBMD, CSA and SSI at 66% tibia site: (A) pre-pubertal males and females, CF (blue or pink) vs Controls; (B) pubertal males and females, CF (blue or pink) vs Controls, mean (SD). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

4 Fig. 3 Relationships of: (A) tibia SSI plotted against age, regression equation: CF SSI=125.94×age−103.5 vs. Control SSI=183.86×age−594.57; ‘intercepts’, p=0.00; ‘slopes’, p=0.03 (B) radius SSI plotted against age, regression equations: CF SSI=15.51×age−15.3 vs. Control radius SSI=21.65×age−62.42, ‘intercepts’, p=0.01; (C) tibia BSIc plotted against age, ‘slopes’, p=0.00; and (D) radius BSIc plotted against age, ‘intercepts’, p=0.05. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

5 Fig. 4 Relationships of: (A) size adjusted tibia mCSA plotted against age, regression equations: CF mCSA/length1.9=0.08×age+4.6 vs. Control mCSA/length1.9=0.2×age+3.6; and (B) radius BSIc plotted against size adjusted mCSA, regression equations: CF BSIc= ×mCSA/length vs. Controls BSIc= ×mCSA/length2.3− Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions


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