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Volume 127, Issue 6, Pages (December 2004)

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Presentation on theme: "Volume 127, Issue 6, Pages (December 2004)"— Presentation transcript:

1 Volume 127, Issue 6, Pages 1863-1864 (December 2004)
Patients with primary biliary cirrhosis make anti-viral and anti-mitochondrial antibodies to mouse mammary tumor virus  Andrew Mason, Lizhe Xu, Zhiwei Shen, Brent Fodera, Ruth Joplin, James Neuberger, Barbara O’Donnell  Gastroenterology  Volume 127, Issue 6, Pages (December 2004) DOI: /j.gastro Copyright © 2004 American Gastroenterological Association Terms and Conditions

2 Figure 1 Immunoblots of (A) Mm5MT cytosolic extracts and (B) extracellular MMTV purified from milk curd in weanling pups stomachs. Serologic reactivity to PBC patient serum and affinity purified AMA from PBC serum was observed to proteins at a molecular weight consistent with the mitochondrial autoantigens PDC-E2 at 74 kilodalton and PDC-E3 binding protein at 57 kilodalton (arrowheads). While incubation with 50 μmol bovine PDC-E2 abrogated reactivity to the 74 kilodalton and 57 kilodalton bands (PDC-E2 +), it had little effect on PBC patient reactivity to gp52 and other characterized MMTV proteins (PDC-E2 -). Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2004 American Gastroenterological Association Terms and Conditions


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