1. Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.170
Figure 5 Effect of dapagliflozin on tissue sensitivity to insulin and β-cell function
Figure 5 | Effect of dapagliflozin on tissue sensitivity to insulin and β-cell function. Treatment of patients with type 2 diabetes mellitus with dapagliflozin for 14 days led to a 25–30% improvement in muscle sensitivity to insulin (part a) and a nearly twofold increase in β-cell function (part b). The improvement in these two parameters resulted from the amelioration of glucotoxicity (that is, a reduction in plasma glucose concentration secondary to glucosuria) and contributed to improvements in overall glucose homeostasis. Part a modified with permission from Merovci, A. et al. J. Clin. Invest. 124, 509–514 (2014). Part b modified with permission from Merovci, A. et al. J. Clin. Endocrinol. Metab. 100, 1927–1932 (2015); permission conveyed through Copyright Clearance Center, Inc.
Part a modified with permission from Merovci, A.et al. J. Clin. Invest. 124, 509–514 (2014). Part b modified with permission from Merovci, A. et al. J. Clin. Endocrinol. Metab. 100, 1927–1932 (2015); permission conveyed through Copyright Clearance Center, Inc.
DeFronzo, R. A. et al. (2016) Renal, metabolic and cardiovascular considerations of SGLT2 inhibition
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