1. Update on NSAID Use:

2. NSAIDS: The Heart of the Controversy

3. How NSAIDs Work

4. NSAIDs: COX-1 and COX-2 Effects

5. NSAID-Aspirin Interaction Competitive Inhibition of COX in the Platelet?

6. CV Risks: an Ongoing Concern

7. Historical Data on CV Risks of NSAIDs

8. Mechanism of NSAID-Related Cardiotoxicity In Vitro Effects

9. NSAIDs and HF Clinical Effects

10. Revisiting the Question of Direct Cardiotoxicity of NSAIDs

11. The Link Between HF and Specific NSAIDs

12. Dose-Related AEs of Meloxicam

13. Meta-Analysis of CV Risk With NSAIDs

14. Meta-Analysis of CV Risk With NSAIDs Rofecoxib Stands Out

15. PRECISION Trial Design

16. PRECISION: Top-Line Results

17. PRECISION: Limitations of Methodology

18. PRECISION: Limitations of Study Population

19. PRECISION: No Information About NSAID-Aspirin Interaction

20. PRECISION: Concerns About Pharmacoequivalence

21. Does PRECISION Help Us Take Care of Patients With Excess CV Risk?

22. Does PRECISION Help Us Take Care of Patients With Excess CV Risk
Does PRECISION Help Us Take Care of Patients With Excess CV Risk? (cont)

23. Take-Home Messages

24. Summary